Head PreClinical- Animal Pharmacology (Himachal Pradesh)

VENUS MEDICINE RESEARCH CENTRE (VMRC) Position: Head – Animal Pharmacology & Toxicology Department: Preclinical Sciences Reports To: Chief Scientific Officer Location: On-site, Full-time Role Overview VMRC is advancing a diversified pipeline spanning novel anti-infectives, BL+BLI combinations, and differentiated herbal therapeutics. The Head – Animal Pharmacology & Toxicology will lead all in vivo pharmacology, ADME, toxicology, translational PK–PD, and pharmacometrics activities across the portfolio. This is a senior scientific leadership role requiring deep expertise in anti-infective development, renal pharmacology, nephrotoxicity assessment, PK–PD modelling, and IND-enabling toxicology, combined with strong regulatory and team leadership capability. Key Programmes Renal Guard Programme (Phase 1) A reformulated polymyxin programme focused on reducing nephrotoxicity while maintaining antimicrobial efficacy. Key areas:
- Renal injury biomarkers: KIM-1, NGAL, Cystatin C, NAG, Osteopontin
- Renal pharmacology and drug disposition
- Histopathology integration
- Complex PK interpretation in limited-literature settings

Meropenem + MET-X Programme (Late Preclinical) A BL+BLI combination targeting carbapenem-resistant Gram-negative infections. Key areas:
- IND-enabling ADME and toxicology
- Translational PK–PD
- Monte Carlo simulation & PTA
- Dose optimisation using:
- fT>MIC
- fAUC/MIC
- Cmax/MIC
- Clinical dose projection and resistance suppression strategy

Qualifications & Experience
- Ph.D. in Pharmacology, Toxicology, Pharmaceutical Sciences, Translational Medicine, or related discipline
- 10+ years in preclinical in vivo drug development
- 5+ years leading multidisciplinary preclinical teams
- Experience advancing assets through IND/CTA-enabling development
- Robust expertise in:
- Anti-infectives
- Toxicology
- Renal pharmacology
- PK–PD/pharmacometrics
- GLP laboratory and regulatory submission experience preferred
- Strong publication and scientific presentatio Apply on Kit Job: kitjob.in/job/4m2x7z