Head Preclinical Animal Pharmacology Himachal Pradesh

VENUS MEDICINE RESEARCH CENTRE (VMRC)

Position: Head – Animal Pharmacology & Toxicology

Department: Preclinical Sciences

Reports To: Chief Scientific Officer

Location: On-site, Full-time

Role Overview

VMRC is advancing a diversified pipeline spanning novel anti-infectives, BL+BLI combinations, and differentiated herbal therapeutics. The Head – Animal Pharmacology & Toxicology will lead all in vivo pharmacology, ADME, toxicology, translational PK–PD, and pharmacometrics activities across the portfolio.

This is a senior scientific leadership role requiring deep expertise in anti-infective development, renal pharmacology, nephrotoxicity assessment, PK–PD modelling, and IND-enabling toxicology, combined with robust regulatory and team leadership capability.

Key Programmes

Renal Guard Programme (Phase 1)

A reformulated polymyxin programme focused on reducing nephrotoxicity while maintaining antimicrobial efficacy.

Key areas:

Renal injury biomarkers: KIM-1, NGAL, Cystatin C, NAG, Osteopontin

Renal pharmacology and drug disposition

Histopathology integration

Complex PK interpretation in limited-literature settings

Meropenem + MET-X Programme (Late Preclinical)

A BL+BLI combination targeting carbapenem-resistant Gram-negative infections.

Key areas:

IND-enabling ADME and toxicology

Translational PK–PD

Monte Carlo simulation & PTA

Dose optimisation using:

fT>MIC

fAUC/MIC

Cmax/MIC

Clinical dose projection and resistance suppression strategy

Qualifications & Experience

Ph.D. in Pharmacology, Toxicology, Pharmaceutical Sciences, Translational Medicine, or related discipline

10+ years in preclinical in vivo drug development

5+ years leading multidisciplinary preclinical teams

Experience advancing assets through IND/CTA-enabling development

Robust expertise in:

Anti-infectives

Toxicology

Renal pharmacology

PK–PD/pharmacometrics

GLP laboratory and regulatory submission experience preferred

Robust publication and scientific presentatio Apply on Kit Job: kitjob.in/job/4mg2qf